The course covers mathematical and computational techniques needed to solve advanced problems encountered in applied bioengineering. Fundamental concepts are presented in the context of their application to biological and physiological problems including cancer, cardiovascular disease, infectious disease, and systems biology. Topics include Taylor's Series expansions, parameter estimation, regression, nonlinear equations, linear systems, optimization, numerical differentiation and integration, stochastic methods, ordinary differential equations and Fourier series. Python, Matlab and other software will be used for weekly assignments and projects.