This is a list of some of our ongoing projects. Our research spans numerical methods development to clinical application of cardiovacsular modeling methods in pediatric and adult cardiovascular disease.
Pediatric and Congenital Heart Disease
Coronary Artery Hemodynamics
Lab members: Owais Khan, Suhaas Anbazhakan, Jongmin Seo
Our lab is performing patient specific modeling of coronary artery hemodynamics in children and adults. In adults, we are simulating coronary bypass graft surgery to elucidate causes of vein graft failure. Vein grafts fail at alarmingly high rates of nearly 50% within 5-10 years of surgery. We use multiscale modeling tools to characterize and compare the in vivo environment of arterial and vein grafts to uncover mechanisms for vein graft failure. We also use virtual surgery to evaluate optimal surgical methods for individual patients. In children, we are using patient specific modeling to evaluate the risk of thrombosis in patients with coronary artery aneurysms caused by Kawasaki disease. We are also exploring the functional significance of collateral arteries in the coronaries in a collaboration with developmental biologists.